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Global Cryo-electron Microscopy Market to reach USD 2.6 billion by the end of 2030

Global Cryo-electron Microscopy Market Size study & Forecast, by Product & Service (Instruments, Fully Automated Instruments, Semi-Automated Instruments, Software, Services), by Technology (Electron Crystallography, Single Particle Analysis, Cryo-electron Tomography, Other Technologies), by Voltage (300 kV, 200 kV, 120 kV), by Application (Life Science Research & Academia, Cancer Research, Omics Research, Pharma & Biotech Manufacturing, Cell & Gene Therapy, Vaccines, Preclinical & Clinical Research, Healthcare/Medical Research, Disease Diagnosis & Pathology, Toxicology Studies, Material Analysis, Nanotechnology, Other Applications) and Regional Analysis, 2023-2030

Product Code: HLSB-80692157
Publish Date: 10-08-2023
Page: 200

Global Cryo-electron Microscopy Market is valued approximately USD 1.1 billion in 2022 and is anticipated to grow with a healthy growth rate of more than 11.6% over the forecast period 2023-2030. Cryo-electron microscopy (Cryo-EM) is a cutting-edge imaging technique used in structural biology to visualize the three-dimensional structures of biological samples, such as proteins and macromolecular complexes, at near-atomic resolution. This technique has revolutionized the field of structural biology, enabling the study of previously inaccessible targets and contributing to advancements in drug discovery, bimolecular research, and understanding the fundamental mechanisms of life. The market drivers boosting the growth are increasing trials of cell and gene therapies and increasing demand for high-resolution imaging.

Cryo-EM plays a crucial role in characterizing the structures and interactions of viral vectors, gene delivery systems, and modified cells used in cell and gene therapies. By providing high-resolution imaging, Cryo-EM enables researchers to gain insights into the mechanisms and behavior of these therapies at the molecular level. According to Statista, in 2022, the United States witnessed over 574 ongoing clinical trials for cell and gene therapies, while Europe hosted 256 trials in the same domain. Moreover, increasing demand for Cryo-EM services and integration of Cryo-EM data with computational approaches is expected to create abundant opportunities. However, the high cost of Cryo-electron equipment and infrastructure and limited availability of skilled rofessionals stifles market growth throughout the forecast period of 2023-2030.

The key regions considered for the Global Cryo-electron Microscopy Market study includes Asia Pacific, North America, Europe, Latin America, and Middle East & Africa. North America dominated the market in 2022 due to an increase in funding to support research activities, an increase in the number of clinical trials, and expanding applications in the healthcare and medical sectors. However, Asia Pacific is expected to become the fastest growing during the forecast period, owing to factors such as growing adoption of Cryo-EM in the pharma industry due to its expanding applications and rising R&D expenditure by government to support advancements in the field.

Major market player included in this report are:
Molecular Devices, LLC.
Intertek Group plc
Nikon Instruments Inc.
Thermo Fisher Scientific Inc.
Olympus Corporation
Helmet Hund GmbH
NanoFocus AG
Lasertec Corporation
Keyence Corporation
Recent Developments in the Market:
Ø In June 2022, Hitachi High-Tech Corporation launched the AFM100, a state-of-the-art microscope that brings substantial advancements in sensitivity for measuring physical properties. This cutting-edge instrument enables precise measurements at the atomic and molecular scale, opening up new possibilities for scientific research and exploration.
Ø In February 2022, Thermo Fisher Scientific completed the acquisition of Eikon Therapeutics, a startup specializing in Cryo-EM technology for drug discovery and structural biology research. This strategic acquisition will enhance Thermo Fisher’s presence in the Cryo-EM market, reinforcing its leadership and expanding its capabilities in providing advanced solutions for customers in the field of structural biology and drug discovery.

Global Cryo-electron Microscopy Market Report Scope:
ü Historical Data – 2020 – 2021
ü Base Year for Estimation – 2022
ü Forecast period – 2023-2030
ü Report Coverage – Revenue forecast, Company Ranking, Competitive Landscape, Growth factors, and Trends
ü Segments Covered – Product & Service, Technology, Voltage, Application, Region
ü Regional Scope – North America; Europe; Asia Pacific; Latin America; Middle East & Africa
ü Customization Scope – Free report customization (equivalent up to 8 analyst’s working hours) with purchase. Addition or alteration to country, regional & segment scope*

The objective of the study is to define market sizes of different segments & countries in recent years and to forecast the values to the coming years. The report is designed to incorporate both qualitative and quantitative aspects of the industry within countries involved in the study.

The report also caters detailed information about the crucial aspects such as driving factors & challenges which will define the future growth of the market. Additionally, it also incorporates potential opportunities in micro markets for stakeholders to invest along with the detailed analysis of competitive landscape and product offerings of key players. The detailed segments and sub-segment of the market are explained below:

By Product & Service:
Fully Automated Instruments
Semi-Automated Instruments
By Technology:
Electron Crystallography
Single Particle Analysis
Cryo-electron Tomography
Other Technologies
By Voltage:
300 kV
200 kV
120 kV
By Application:
Life Science Research & Academia
Cancer Research
Omics Research
Pharma & Biotech Manufacturing
Cell & Gene Therapy
Preclinical & Clinical Research
Healthcare/Medical Applications
Disease Diagnosis & Pathology
Toxicology Studies
Material Analysis
Other Applications

By Region:

North America


Asia Pacific
South Korea

Latin America

Middle East & Africa
Saudi Arabia
South Africa
Rest of Middle East & Africa

Chapter 1. Executive Summary
1.1. Market Snapshot
1.2. Global & Segmental Market Estimates & Forecasts, 2020-2030 (USD Billion)
1.2.1. Cryo-electron Microscopy Market, by Region, 2020-2030 (USD Billion)
1.2.2. Cryo-electron Microscopy Market, by Product & Service, 2020-2030 (USD Billion)
1.2.3. Cryo-electron Microscopy Market, by Technology, 2020-2030 (USD Billion)
1.2.4. Cryo-electron Microscopy Market, by Voltage, 2020-2030 (USD Billion)
1.2.5. Cryo-electron Microscopy Market, by Application, 2020-2030 (USD Billion)
1.3. Key Trends
1.4. Estimation Methodology
1.5. Research Assumption
Chapter 2. Global Cryo-electron Microscopy Market Definition and Scope
2.1. Objective of the Study
2.2. Market Definition & Scope
2.2.1. Industry Evolution
2.2.2. Scope of the Study
2.3. Years Considered for the Study
2.4. Currency Conversion Rates
Chapter 3. Global Cryo-electron Microscopy Market Dynamics
3.1. Cryo-electron Microscopy Market Impact Analysis (2020-2030)
3.1.1. Market Drivers Advancements in Cryo-EM technology Increasing demand for high-resolution imaging
3.1.2. Market Challenges High Cost of Cryo-electron equipment and infrastructure Limited availability of skilled professionals
3.1.3. Market Opportunities Increasing demand for Cryo-EM services Integration of Cryo-EM data with computational approaches
Chapter 4. Global Cryo-electron Microscopy Market Industry Analysis
4.1. Porter’s 5 Force Model
4.1.1. Bargaining Power of Suppliers
4.1.2. Bargaining Power of Buyers
4.1.3. Threat of New Entrants
4.1.4. Threat of Substitutes
4.1.5. Competitive Rivalry
4.2. Porter’s 5 Force Impact Analysis
4.3. PEST Analysis
4.3.1. Political
4.3.2. Economical
4.3.3. Social
4.3.4. Technological
4.3.5. Environmental
4.3.6. Legal
4.4. Top investment opportunity
4.5. Top winning strategies
4.6. COVID-19 Impact Analysis
4.7. Disruptive Trends
4.8. Industry Expert Perspective
4.9. Analyst Recommendation & Conclusion
Chapter 5. Global Cryo-electron Microscopy Market, by Product & Service
5.1. Market Snapshot
5.2. Global Cryo-electron Microscopy Market by Product & Service, Performance – Potential Analysis
5.3. Global Cryo-electron Microscopy Market Estimates & Forecasts by Product & Service 2020-2030 (USD Billion)
5.4. Cryo-electron Microscopy Market, Sub Segment Analysis
5.4.1. Instruments
5.4.2. Fully Automated Instruments
5.4.3. Semi-Automated Instruments
5.4.4. Software
5.4.5. Services
Chapter 6. Global Cryo-electron Microscopy Market, by Technology
6.1. Market Snapshot
6.2. Global Cryo-electron Microscopy Market by Technology, Performance – Potential Analysis
6.3. Global Cryo-electron Microscopy Market Estimates & Forecasts by Technology 2020-2030 (USD Billion)
6.4. Cryo-electron Microscopy Market, Sub Segment Analysis
6.4.1. Electron Crystallography
6.4.2. Single Particle Analysis
6.4.3. Cryo-electron Tomography
6.4.4. Other Technologies
Chapter 7. Global Cryo-electron Microscopy Market, by Voltage
7.1. Market Snapshot
7.2. Global Cryo-electron Microscopy Market by Voltage, Performance – Potential Analysis
7.3. Global Cryo-electron Microscopy Market Estimates & Forecasts by Voltage 2020-2030 (USD Billion)
7.4. Cryo-electron Microscopy Market, Sub Segment Analysis
7.4.1. 300 kV
7.4.2. 200 kV
7.4.3. 120 kV
Chapter 8. Global Cryo-electron Microscopy Market, by Application
8.1. Market Snapshot
8.2. Global Cryo-electron Microscopy Market by Application, Performance – Potential Analysis
8.3. Global Cryo-electron Microscopy Market Estimates & Forecasts by Application 2020-2030 (USD Billion)
8.4. Cryo-electron Microscopy Market, Sub Segment Analysis
8.4.1. Life Science Research & Academia
8.4.2. Cancer Research
8.4.3. Omics Research
8.4.4. Pharma & Biotech Manufacturing
8.4.5. Cell & Gene Therapy
8.4.6. Vaccines
8.4.7. Preclinical & Clinical Research
8.4.8. Healthcare/Medical Applications
8.4.9. Disease Diagnosis & Pathology
8.4.10. Toxicology Studies
8.4.11. Material Analysis
8.4.12. Nanotechnology
8.4.13. Other Applications
Chapter 9. Global Cryo-electron Microscopy Market, Regional Analysis
9.1. Top Leading Countries
9.2. Top Emerging Countries
9.3. Cryo-electron Microscopy Market, Regional Market Snapshot
9.4. North America Cryo-electron Microscopy Market
9.4.1. U.S. Cryo-electron Microscopy Market Product & Service breakdown estimates & forecasts, 2020-2030 Technology breakdown estimates & forecasts, 2020-2030 Voltage breakdown estimates & forecasts, 2020-2030 Application breakdown estimates & forecasts, 2020-2030
9.4.2. Canada Cryo-electron Microscopy Market
9.5. Europe Cryo-electron Microscopy Market Snapshot
9.5.1. U.K. Cryo-electron Microscopy Market
9.5.2. Germany Cryo-electron Microscopy Market
9.5.3. France Cryo-electron Microscopy Market
9.5.4. Spain Cryo-electron Microscopy Market
9.5.5. Italy Cryo-electron Microscopy Market
9.5.6. Rest of Europe Cryo-electron Microscopy Market
9.6. Asia-Pacific Cryo-electron Microscopy Market Snapshot
9.6.1. China Cryo-electron Microscopy Market
9.6.2. India Cryo-electron Microscopy Market
9.6.3. Japan Cryo-electron Microscopy Market
9.6.4. Australia Cryo-electron Microscopy Market
9.6.5. South Korea Cryo-electron Microscopy Market
9.6.6. Rest of Asia Pacific Cryo-electron Microscopy Market
9.7. Latin America Cryo-electron Microscopy Market Snapshot
9.7.1. Brazil Cryo-electron Microscopy Market
9.7.2. Mexico Cryo-electron Microscopy Market
9.8. Middle East & Africa Cryo-electron Microscopy Market
9.8.1. Saudi Arabia Cryo-electron Microscopy Market
9.8.2. South Africa Cryo-electron Microscopy Market
9.8.3. Rest of Middle East & Africa Cryo-electron Microscopy Market

Chapter 10. Competitive Intelligence
10.1. Key Company SWOT Analysis
10.1.1. Company 1
10.1.2. Company 2
10.1.3. Company 3
10.2. Top Market Strategies
10.3. Company Profiles
10.3.1. Molecular Devices, LLC. Key Information Overview Financial (Subject to Data Availability) Product Summary Recent Developments
10.3.2. Intertek Group plc
10.3.3. JEOL Ltd.
10.3.4. Nikon Instruments Inc.
10.3.5. Thermo Fisher Scientific Inc.
10.3.6. Olympus Corporation
10.3.7. Helmet Hund GmbH
10.3.8. NanoFocus AG
10.3.9. Lasertec Corporation
10.3.10. Keyence Corporation
Chapter 11. Research Process
11.1. Research Process
11.1.1. Data Mining
11.1.2. Analysis
11.1.3. Market Estimation
11.1.4. Validation
11.1.5. Publishing
11.2. Research Attributes
11.3. Research Assumption

At Bizwit Research and Consultancy, we employ a thorough and iterative research methodology with the goal of minimizing discrepancies, ensuring the provision of highly accurate estimates and predictions over the forecast period. Our approach involves a combination of bottom-up and top-down strategies to effectively segment and estimate quantitative aspects of the market, utilizing our proprietary data & AI tools. Our Proprietary Tools allow us for the creation of customized models specific to the research objectives. This enables us to develop tailored statistical models and forecasting algorithms to estimate market trends, future growth, or consumer behavior. The customization enhances the accuracy and relevance of the research findings.
We are dedicated to clearly communicating the purpose and objectives of each research project in the final deliverables. Our process begins by identifying the specific problem or challenge our client wishes to address, and from there, we establish precise research questions that need to be answered. To gain a comprehensive understanding of the subject matter and identify the most relevant trends and best practices, we conduct an extensive review of existing literature, industry reports, case studies, and pertinent academic research.
Critical elements of methodology employed for all our studies include:
Data Collection:
To determine the appropriate methods of data collection based on the research objectives, we consider both primary and secondary sources. Primary data collection involves gathering information directly from various industry experts in core and related fields, original equipment manufacturers (OEMs), vendors, suppliers, technology developers, alliances, and organizations. These sources encompass all segments of the value chain within the specific industry. Through in-depth interviews, we engage with key industry participants, subject-matter experts, C-level executives of major market players, industry consultants, and other relevant experts. This allows us to obtain and validate critical qualitative and quantitative information while evaluating market prospects. AI and Big Data are instrumental in our primary research, providing us with powerful tools to collect, analyze, and derive insights from data efficiently. These technologies contribute to the advancement of research methodologies, enabling us to make data-driven decisions and uncover valuable findings.
In addition to primary sources, we extensively utilize secondary sources to enhance our research. These include directories, databases, journals focusing on related industries, company newsletters, and information portals such as Bloomberg, D&B Hoovers, and Factiva. These secondary sources enable us to identify and gather valuable information for our comprehensive, technical, market-oriented, and commercial study of the market. Additionally, we utilize AI algorithms to automate the collection of vast amounts of data from various sources such as surveys, social media platforms, online transactions, and web scraping. And employ Big Data technologies for storage and processing of large datasets, ensuring that no valuable information is missed during the data collection process.
Data Analysis:
Our team of experts carefully examine the gathered data using suitable statistical techniques and qualitative analysis methods. For quantitative analysis, we employ descriptive statistics, regression analysis, and other advanced statistical methods, depending on the characteristics of the data. This analysis may also incorporate the utilization of AI tools and big data analysis techniques to extract meaningful insights.
To ensure the accuracy and reliability of our findings, we extensively leverage data science techniques, which help us minimize discrepancies and uncertainties in our analysis. We employ Data Science to clean and preprocess the data, ensuring its quality and reliability. This involves handling missing data, removing outliers, standardizing variables, and transforming data into suitable formats for analysis. The application of data science techniques enhances our accuracy, efficiency, and depth of analysis, enabling us to stay competitive in dynamic market environments.
Market Size Estimation:
Our proprietary data tools play a crucial role in deriving our market estimates and forecasts. Each study involves the creation of a unique and customized model. The model incorporates the gathered information on market dynamics, technology landscape, application development, and pricing trends. AI techniques, such as machine learning and deep learning, aid us to analyze patterns within the data to identify correlations, trends, and relationships. By recognizing patterns in consumer behavior, purchasing habits, or market dynamics, our AI algorithms aid us in more precise estimations of market size. These factors are simultaneously analyzed within the model, allowing for a comprehensive assessment. To quantify their impact over the forecast period, correlation, regression, and time series analysis are employed.
To estimate and validate the market size, we employ both top-down and bottom-up approaches. The preference is given to a bottom-up approach, where key regional markets are analyzed as separate entities. This data is then integrated to obtain global estimates. This approach is crucial as it provides a deep understanding of the industry and helps minimize errors.
In our forecasting process, we consider various parameters such as economic tools, technological analysis, industry experience, and domain expertise. By taking all these factors into account, we strive to produce accurate and reliable market forecasts. When forecasting, we take into consideration several parameters, which include:
Market driving trends and favorable economic conditions
Restraints and challenges that are expected to be encountered during the forecast period.
Anticipated opportunities for growth and development
Technological advancements and projected developments in the market
Consumer spending trends and dynamics
Shifts in consumer preferences and behaviors.
The current state of raw materials and trends in supply versus pricing
Regulatory landscape and expected changes or developments.
The existing capacity in the market and any expected additions or expansions up to the end of the forecast period.
To assess the market impact of these parameters, we assign weights to each one and utilize weighted average analysis. This process allows us to quantify their influence on the market and derive an expected growth rate for the forecasted period. By considering these various factors and applying a weighted analysis approach, we strive to provide accurate and reliable market forecasts.
Insight Generation & Report Presentation:
After conducting the research, our experts analyze the findings in relation to the research objectives and the specific needs of the client. They generate valuable insights and recommendations that directly address the client’s business challenges. These insights are carefully connected to the research findings to provide a comprehensive understanding.
Next, we create a well-structured research report that effectively communicates the research findings, insights, and recommendations to the client. To enhance clarity and comprehension, we utilize visual aids such as charts, graphs, and tables. These visual elements are employed to present the data in an engaging and easily understandable format, ensuring that the information is accessible and visually appealing to the client. Our aim is to deliver a clear and concise report that conveys the research findings effectively and provides actionable recommendations to meet the client’s specific needs.

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